I am currently a fourth-year PhD candidate at Artificial Intelligencein Healthcare (AIH) group and Machine Intelligence and Social Computing (MISC) Lab of The Chinese University of Hong Kong, supervised by Prof. Yu Li and Prof. Irwin King. Before that, I received the Bachelor’s degree in Applied Mathematics from Harbin Institute of Technology in 2022.

My research interest includes computational challenges in biology and healthcare, especially that related to single-cell data.

🔥 News

  • 2025.07:  🎉🔥 CRISP was accepted by nature computational science.
  • 2025.03:  🚀 Awarded the RECOMB 2025 Conference Travel Fellowship.
  • 2025.01:   One paper accepted by RECOMB 2025.
  • 2024.11:  🎉🎉 RhoFold+ & RNA-FM is published in Nature Methods.
  • 2024.09:   One survey paper published Briefings in Bioinformatics.
  • 2024.09:   One paper accepted by NeurIPS 2024.
  • 2024.08:   Visit MBZUAI as a research assocaite, supervised by Prof. Le Song and Prof. Eric Xing.
  • 2024.06:  🎉 Pass the Ph.D. candidate qualification.
  • 2024.03:   scNovel is published Briefings in Bioinformatics.

📖 Educations

📝 Publications

†: equal contribution

RECOMB 2025
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cfDecon: Accurate and Interpretable methylation-based cell type deconvolution for cell-free DNA

Yixuan Wang, Jiayi Li, Jingqi Li, Shen Yang, Yuhan Huang, Xinyuan Liu, Yimin Fan, Irwin King, Yumei Li, Yu Li

Paper / Project / Code

Nature Methods 2024
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Accurate RNA 3D Structure Prediction using A Language Model-based Deep Learning Approach

Tao Shen, Zhihang Hu, Siqi Sun, Di Liu, Felix Wong, Jiuming Wang, Jiayang Chen, Yixuan Wang, Liang Hong, Jin Xiao, Liangzhen Zheng, Tejas Krishnamoorthi, Irwin King, Sheng Wang, Peng Yin, James J. Collins and Yu Li

Paper / Project / Code

Briefings in Bioinformatics 2024
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scNovel: A Scalable Deep Learning‑based Network for Novel Rare Cell Discovery in Single‑cell Transcriptomics

Chuanyang Zheng, Yixuan Wang, Yuqi Cheng, Xuesong Wang, Hongxin Wei, Irwin King, Yu Li

Paper / Project / Code

Nature Communications 2022
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Deep Autoencoder for Interpretable Tissue‑adaptive Deconvolution and Cell‑type‑specific Gene Analysis

Yanshuo Chen, Yixuan Wang, Yuelong Chen, Yuqi Cheng, Yumeng Wei, Yunxiang Li, Jiuming Wang, Yingying Wei, Ting-Fung Chan, Yu Li

Paper / Project / Code

🎖 Honors and Awards

  • 2025.03: The RECOMB 2025 Conference Travel Fellowship.
  • 2022.10: Most Ten of the Outstanding Undergraduate, for international influence (individual).
  • 2020.10: National Scholarship at HIT.
  • 2020.09: International Finalist Winner, Mathematical Contest in Modeling-MCM (leader).

💬 Invited Talks

  • 2024.04, Discovering Novel Rare Cell Types from Single-Cell RNA Sequencing Using Deep Learning. | [introduction]

💻 Internships